Michigan State improved to 10-2 in the Big 10 and 20-4 overall, holding Michigan to 35% shooting in a 54-42 road win.
Freshman Delvon Roe scored 14 points and had 10 boards in a season-high effort. Kalin Lucas led the Spartans with 15 points.
It was Michigan State's third straight win and also the third straight game in which their opponent has tallied 47 or fewer points. The Spartans are a perfect 18-0 when holding their opponent to 67 points or less.
Michigan St. leads Ohio State and Illinois by 2 1/2 games in the conference, seeking its first Big 10 title since 2001.
Elsewhere, #25 Florida St. shot a blistering 71% in a 48-point second half, cruising past Virginia, 58-67. #12 Clemson rolled past Boston College, 87-77.
Jodie Meeks hit a pair of free throws in the final minute and banged home a three-pointer with 9.8 seconds remaining to give Kentucky a 68-65 win over the Florida Gators in a key SEC matchup. Florida's Nick Calathes poured in 33 points but misfired on all three potentially game-tying free throws with 1 second left. Meeks led the Wildcats with 23.